Oncogene FPS-FES

**Semantic type:** Gene or Genome

**Definition:** Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. Oncogene FPS-FES disrupts normal cell function.

**Synonyms:** - FES - FPS - Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene - Oncogene FES