E3 Ubiquitin-Protein Ligase Arkadia

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase Arkadia (994 aa, ~109 kDa) is encoded by the human RNF111 gene. This protein plays a role in the modulation of SMAD protein degradation.

**Synonyms:** - EC 2.3.2.27 - RING Finger Protein 111 - RING-Type E3 Ubiquitin Transferase Arkadia - RNF111 - hRNF111