BGT226 Maleate

**Semantic type:** Pharmacologic Substance

**Definition:** The maleate form of BGT226, a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Upon administration, BGT226 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.

**Synonyms:** - 2H-imidazo(4,5-C)quinolin-2-one, 1,3-Dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-(4-(1-piperazinyl)-3-(trifluoromethyl)phenyl)-, (2Z)-2-butenedioate (1:1) - BGT-226 MALEATE - NVP-BGT-226 Maleate - NVP-BGT226 Maleate - PI3K Inhibitor BGT226 Maleate