Phosphatidylinositide 3-Kinase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3 position hydroxyl group of the inositol ring of phosphatidylinositol and functions as an intracellular signal transducer in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. Inhibition of phosphatidylinositol 3-kinase produces antiproliferative and antiangiogenic effects.

**Synonyms:** - PI3-Kinase Inhibitors - PI3K Inhibitor - PI3K Inhibitor - Phosphatidylinositol 3-kinase Inhibitor - Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Inhibitor