SRC Family Oncogene

**Semantic type:** Gene or Genome

**Definition:** Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which encode diverse SRC Family Tyrosine Kinases, closely related intracellular non-receptor protein-tyrosine kinases with amino acid sequence similarity to SRC and to Rous sarcoma virus oncogene protein PP60(V-SRC). SRC tyrosine kinases interact with diverse cell-surface receptors and participate in intracellular signal transduction pathways in a variety of hematopoietic cells. Oncogenic SRC kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes. SRC family oncogenes disrupt normal cell function.