Paclitaxel-loaded Tumor Penetrating Microparticles

**Semantic type:** Pharmacologic Substance

**Definition:** A microparticle-based suspension containing the water-insoluble taxane paclitaxel, with potential antineoplastic activity. Upon intraperitoneal administration of paclitaxel-loaded tumor penetrating microparticles (TPM), the microparticles may adhere to tumor cells, and paclitaxel binds to and stabilizes tubulin molecules, which results in the inhibition of both microtubule depolymerization and cell division. Paclitaxel also induces apoptosis by both binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2).

**Synonyms:** - Paclitaxel-loaded Microparticles Suspension - Paclitaxel-loaded TPM