IGH/MAFB Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation, t(14;20)(q32;q12), which fuses transcriptional enhancers from the immunoglobulin heavy chain (IGH) gene locus with the promoter region of the MAFB gene. This rearrangement is associated with multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, plasma cell leukemia and plasmacytoma.

**Synonyms:** - IGH-MAFB - IGH-MAFB Fusion Gene - IGH::MAFB Fusion Gene - MAFB-IGH - MAFB-IGH Fusion Gene - MAFB/IGH Fusion Gene