CDK2/4/6 Inhibitor RGT-419B

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable third-generation inhibitor of cyclin-dependent kinase (CDK) types 2 (CDK2), 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK2/4/6 inhibitor RGT-419B selectively targets and inhibits CDK2, CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase and prevents CDK-mediated G1-S-phase transition. This leads to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation and are upregulated in many tumor cell types. In addition, RGT-419B may inhibit other kinases.

**Synonyms:** - Cyclin-dependent Kinase 2/4/6 Inhibitor RGT-419B - RGT 419B - RGT-419B - RGT419B