IGH/IL3 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation, t(5;14)(q31;q32), which results in the juxtaposition of a strong transcriptional enhancer from the immunoglobulin heavy chain (IGH) gene locus with the promoter region of the IL3 gene. This rearrangement is associated with B-cell acute lymphoblastic leukemia with hypereosinophilia.

**Synonyms:** - IGH-IL3 - IGH-IL3 Fusion Gene - IGH::IL3 Fusion - IGH::IL3 Fusion Gene