Dominant Negative Receptor

**Semantic type:** Amino Acid, Peptide, or Protein|Receptor

**Definition:** A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative receptor usually has an intact ligand binding region but is missing an intracellular enzymatic region. It may be a mutated form of a full length receptor or it may be in the same receptor family.

**Synonyms:** - Dominant-Negative Receptor