Benzo(a)pyrene-7,8-diol 9,10-Epoxide

**Semantic type:** Hazardous or Poisonous Substance|Organic Chemical|Pharmacologic Substance

**Definition:** A polycyclic aromatic hydrocarbon and metabolite of benzo(a)pyrene with potent cytotoxic and mutagenic properties. Benzo(a)pyrene-7,8-diol-9,10-epoxide binds directly to DNA and disrupts DNA replication.

**Synonyms:** - 8a,9a-Dihydrobenzo(10,11)chryseno(3,4-b)oxirene-7,8-diol - BPDE - Benzo(10,11)chryseno(3,4-b)oxirene-7,8-diol, 8a,9a-dihydro-