HHV-8 and EBV-Negative Primary Effusion-Based Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** An HHV-8 and EBV-negative primary effusion-based lymphoma that affects elderly, HIV-negative patients with history of medical conditions that result in fluid overload. The majority of cases have been reported in Japan. Most tumors exhibit centroblastic or immunoblastic morphology. The prognosis is good.

**Synonyms:** - Fluid Overload-Associated Large B-Cell Lymphoma - HHV-8 and Epstein-Barr Virus-Negative Primary Effusion-Based Lymphoma - Human Herpesvirus-8 and Epstein-Barr Virus-Negative Primary Effusion-Based Lymphoma - KSVH/HHV8-Negative Effusion-Based Lymphoma