TCR-engineered T-cells HRYZ-T101

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of genetically engineered T-lymphocytes expressing a T-cell receptor (TCR) targeting a specific tumor-associated antigen (TAA) of the human papillomavirus (HPV) type 18 (HPV-18), with potential antineoplastic activity. Upon administration, HPV-18 expressing TCR T-cells target and bind to tumor cells expressing the HPV-18 TAA leading to selective cytotoxicity in HPV-18 TAA-expressing tumor cells. HPV18 TAAs are overexpressed in a variety of tumor cell types.

**Synonyms:** - HRYZ T101 - HRYZ-T101 - HRYZT101 - TCR-T Cells HRYZ-T101