G-Quadruplex-selective Transcription Inhibitor QN-302

**Semantic type:** Pharmacologic Substance

**Definition:** A naphthalene diimide (ND) derivative and selective G-quadruplex (G4) transcription inhibitor, with potential antineoplastic activity. Upon administration, QN-302 targets and binds to highly stable G-quadruplex DNA sequences that are prevalent within the promoter regions of cancer-related genes, thereby further stabilizing these complexes. This stabilization prevents unwinding and inhibits transcription factor binding, which leads to an inhibition of target gene transcription and expression and decreases G4-expressing cancer cell proliferation. Specifically, QN-302 downregulates the expression of the S100P gene in tumor cells. S100P, forming many quadruplex-forming sequences, plays a key role in the proliferation and motility pathways in several cancers and is upregulated in various tumor cell types. G4 sequences are over-represented in the promoter regions of many oncogenes.

**Synonyms:** - Cell Penetrating and Capsase-9/PP2A Interaction Interfering Peptide PEP-010 - G4 Transcription Inhibitor QN-302 - QN 302 - QN-302 - QN-302 - QN302 - SOP 1812 - SOP-1812 - SOP1812