Werner Syndrome ATP-Dependent Helicase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang.

**Synonyms:** - DNA Helicase, RecQ-Like Type 3 - EC 3.1.-.- - EC 3.6.4.12 - Exonuclease WRN - RecQ Protein-Like 2 - RecQ3 - WRN - WRN Protein - Werner Syndrome Protein