Treatment Arm for COG ACNS0332 Chemotherapy and Radiation Therapy in Treating Young Patients with Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/ PNET

**Semantic type:** Research Activity

**Definition:** A treatment arm associated with a phase III Children’s Oncology Group trial (ACNS0332) examining if therapy intensification with carboplatin as a radiosensitizer or isotretinoin as a proapoptotic agent increases long term event-free survival in children with high-risk medulloblastoma. (Leary SES, et al. JAMA Oncol. 2021 Sep 1;7(9):1313-1321.)