Phosphate-Regulating Neutral Endopeptidase PHEX

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Phosphate-regulating neutral endopeptidase PHEX (749 aa, ~86 kDa) is encoded by the human PHEX gene. This protein plays a role in the cleavage of biologically active small integrin-binding ligand, N-linked glycoprotein (SIBLING)-derived acidic-serine-aspartate-rich-MEPE-associated (ASARM) motif peptides.

**Synonyms:** - EC 3.4.24.- - HYP - Metalloendopeptidase Homolog PEX - PHEX - Vitamin D-Resistant Hypophosphatemic Rickets Protein - X-Linked Hypophosphatemia Protein