PRKAR1A Gene Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the PRKAR1A gene that inhibits expression or results in the translation of either low-activity or inactive forms of cAMP-dependent protein kinase type I-alpha regulatory subunit protein, which leads to deregulation of protein kinase A-mediated signaling pathways.

**Synonyms:** - Inactivating PKR1 Gene Mutation - Inactivating PRKAR1 Gene Mutation - Inactivating Protein Kinase cAMP-Dependent Type I Regulatory Subunit Alpha Gene Mutation - Inactivating TSE1 Gene Mutation - Loss of Function PRKAR1A Gene Mutation - Loss of Function PRKAR1A Mutation - PRKAR1A Inactivating Gene Mutation - PRKAR1A Inactivating Mutation - PRKAR1A Loss of Function Gene Mutation - PRKAR1A Loss of Function Mutation