E3 Ubiquitin-Protein Ligase CHIP

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase CHIP (303 aa, ~35 kDa) is encoded by the human STUB1 gene. This protein plays a role in the ubiquitination of misfolded chaperone proteins, which promotes the degradation of those misfolded substrates.

**Synonyms:** - Antigen NY-CO-7 - C Terminus of Hsp70-Interacting Protein BIA1 - CLL-Associated Antigen KW-8 - Carboxy Terminus of Hsp70-Interacting Protein - EC 2.3.2.27 - RING-Type E3 Ubiquitin Transferase CHIP - STIP1 Homologous and U Box-Containing Protein 1 - STIP1 Homologous and U-Box Containing Protein 1 - STIP1 Homology and U Box-Containing Protein 1 - STIP1 Homology and U-Box Containing Protein 1 - STUB1