Acute Promyelocytic Leukemia

**Semantic type:** Neoplastic Process

**Definition:** An acute myeloid leukemia characterized by the predominance of abnormal promyelocytes and translocations involving the retinoic acid receptor-α (RARA) gene. Over 95% of cases are characterized by the presence of the reciprocal balanced translocation t(15;17)(q24.1;q21.2) that results in the fusion of the promyelocytic leukemia (PML) gene and RARA gene. The remainder of the cases show variant RARA gene translocations with other genes including NUMA1, ZBTB16, STAT5B, and NPM1.

**Synonyms:** - APL - APL - APL - APML - APML - Acute promyelocytic leukemia - FAB M3 - M3 - M3 - M3 - M3 - acute promyelocytic leukemia - promyelocytic leukemia