Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA

**Semantic type:** Neoplastic Process

**Definition:** An acute promyelocytic leukemia characterized by the reciprocal balanced translocation t(15;17)(q24.1;q21.2) that results in the fusion of the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARA) gene. The t(15;17)(q24.1;q21.2) with the resulting PML-RARA fusion gene occurs in over 95% of cases of acute promyelocytic leukemia. The remainder of the cases show variant RARA gene translocations with other genes.

**Synonyms:** - AML with t(15;17)(q24.1;q21.2) - Acute Promyelocytic Leukemia with PML-RARA - Acute Promyelocytic Leukemia with PML-RARA - Acute Promyelocytic Leukemia with PML-RARA - Acute Promyelocytic Leukemia with PML-RARA - Acute Promyelocytic Leukemia with PML-RARA Fusion - Acute Promyelocytic Leukemia with PML::RARA - Acute Promyelocytic Leukemia with PML::RARA Fusion - Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML/RARA - Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA Fusion - Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML::RARA - Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML::RARA Fusion - Acute promyelocytic leukaemia, PML-RAR-alpha - Acute promyelocytic leukaemia, t(15;17)(q22;q11-12) - M3 OR Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA