CRL4-CRBN E3 Ubiquitin Ligase Complex

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A DCX (DDB1-CUL4-X-box) ubiquitin protein ligase complex that is composed of protein cereblon (CRBN), cullin-4A (CUL4A) or cullin-4B (CUL4B), DNA damage-binding protein 1 (DDB1) and E3 ubiquitin-protein ligase RBX1. This enzyme complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The CRBN moiety regulates substrate recognition.

**Synonyms:** - CRL4(CRBN) - CRL4(CRBN) Ubiquitin Ligase Complex - CRL4-CRBN - CRL4-CRBN E3 Ubiquitin Ligase - CRL4CRBN - CUL4-CRBN E3 Ubiquitin Ligase