Ubiquitin C-Terminal Hydrolase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. The expression of these enzymes is tissue-specific and developmentally regulated. Members of this deubiquitinating family are also important modulators of cellular function. (NCI)

**Synonyms:** - UCH - Ubiquitin Carboxyl-Terminal Hydrolase