Duocarmycin Antineoplastic Antibiotic

**Semantic type:** Chemical Viewed Functionally

**Definition:** A spirocyclopropylhexadienone-containing antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

**Synonyms:** - Duocarmycins