IGH/NSD2 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation, t(4;14)(p16;q32), which juxtaposes the enhancer sequences for the mu-constant region from the immunoglobulin heavy chain (IGH) gene locus upstream of exon 3, 4 or 5 of the NSD2 gene. This rearrangement is associated with multiple myeloma and monoclonal gammopathy of uncertain significance.

**Synonyms:** - IGH-MMSET Fusion Gene - IGH-NSD2 - IGH-NSD2 Fusion - IGH-NSD2 Fusion Gene - IGH-WHSC1 Fusion Gene - IGH/WHSC1 Fusion Gene - IGH::NSD2 Fusion Gene