Acridine Carboxamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.

**Synonyms:** - DACA - DACA - N-(2-(Dimethylamino)ethyl)acridine-4-carboxamide - SN 22995 - XR-5000 - XR5000 - acridine carboxamide