IGH/MYC Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation, t(8;14)(q24;q32), which results in the juxtaposition of a strong transcriptional enhancer from the immunoglobulin heavy chain (IGH) gene locus with either a promoter region for or upstream of exon 2 of the MYC gene. This fusion is associated with Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL).

**Synonyms:** - IGH-MYC - IGH-MYC Fusion Gene - IGH::MYC - IGH::MYC Fusion Gene - MYC/IGH - MYC::IGH