Eflornithine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)

**Synonyms:** - 2-(Difluoromethyl)-DL-ornithine - 2-Difluoromethylornithine - Alpha-Difluoromethylornithine - D,L-alpha-Difluoromethylornithine - DFMO - DFMO - Difluoromethylornithine - Difluromethylornithine - EFLORNITHINE - difluoromethylornithine - eflornithine