Diethylhomospermine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity have been developed.

**Synonyms:** - 1,14-bis(ethylamino)-5,10-diazatetradecane - DEHOP - DEHSPM - DIETHYLHOMOSPERMINE - N(1),N(14)-bis(ethyl)homospermine - N1,N14-diethylhomospermine - N1N14-bis(ethyl)norspermine - N1N14-diethylhomospermine