Gimeracil

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.

**Synonyms:** - 5-Chloro-2,4-pyridinediol - CDHP - Chlorodihydroxypyridine - GIMERACIL