Dihydropyrimidine Dehydrogenase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits dihydropyrimidine dehydrogenase, a rate limiting enzyme in the degradation of pyrimidines. Inhibition of dihydropyrimidine dehydrogenase increases the biological half-life and efficacy of 5-Fluorouracil (5-FU).

**Synonyms:** - DPD Inhibitors - Dihydrothymin Dehydrogenase Inhibitors - Dihydrouracil Dehydrogenase Inhibitors - NADP Inhibitors