Paclitaxel Liposome

**Semantic type:** Pharmacologic Substance

**Definition:** A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity.

**Synonyms:** - LEP-ETU - LipoTaxen - Liposome-Encapsulated Paclitaxel - PNU-93914 - liposomal paclitaxel - paclitaxel liposome