Naxtarubicin

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A lipophilic, anthracycline antineoplastic antibiotic.Naxtarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis. This agent appears to not be a substrate for the p-glycoprotein associated multidrug-resistance (MDR) transporter; therefore, overcoming the resistance pattern seen with other anthracycline compounds.

**Synonyms:** - 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin - 5,12-naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-l-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S-cis)- - Annamycin - NAXTARUBICIN - annamycin