Pixantrone

**Semantic type:** Pharmacologic Substance

**Definition:** A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.

**Synonyms:** - 6,9-Bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione - PIXANTRONE - pixantrone