Colchicine-Site Binding Agent ABT-751

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04)

**Synonyms:** - ABT-751 - ABT-751 - ABT-751 - ABT-751 - E 7010 - E-7010 - E7010 - N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide - N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide