Recombinant Vaccinia-TRICOM Vaccine

**Semantic type:** Chemical Viewed Functionally

**Definition:** A vaccine consisting of recombinant vaccinia virus encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-TRICOM vaccine stimulates the host immune system to mount a non-specific T-cell response. With the addition of a tumor-associated antigen peptide, this vaccine may enhance a tumor-specific immune response.

**Synonyms:** - Vaccinia-TRICOM - rV-TRICOM - rV-TRICOM - recombinant vaccinia-TRICOM vaccine - vaccinia-TRICOM vaccine