Inalimarev

**Semantic type:** Pharmacologic Substance|Virus

**Definition:** A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.

**Synonyms:** - PANVAC-V - PANVAC-V - Vaccinia-CEA-MUC1-TRICOM Vaccine - inalimarev - rVaccinia-CEA(D609)/MUC1(L93)/TRICOM Vaccine - recombinant vaccinia-CEA-MUC-1-TRICOM vaccine