Combretastatin A-4

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An inhibitor of microtubule polymerization derived from the South African willow bush which causes mitotic arrest and selectively targets and reduces or destroys existing blood vessels, causing decreased tumor blood supply.

**Synonyms:** - 1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene - 3,4,5-Trimethoxy-3'-hydroxy-4'-methoxystilbene - COMBRESTATIN A4 - Combretastatin A4 - Crc 87-09 - Crc-98-09