Vitaxin-2

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A modified version of Vitaxin, a humanized monoclonal IgG1 antibody to alpha(v)beta(3)integrin. Exhibiting improved affinity to alpha(v)beta(3)integrin compared to first-generation Vitaxin, Vitaxin-2 blocks the binding of ligands, such as vitronectin, to alpha(v)beta(3) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)

**Synonyms:** - Monoclonal Antibody Anti-Avb3 Integrin - Vitaxin 2