Pyroxamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04)

**Synonyms:** - PYROXAMIDE - Suberoyl-3-aminopyridineamide Hydroxamic Acid - pyroxamide