Ketotrexate Disodium

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The sodium salt of ketotrexate, a synthetic antimetabolite analogue of folate with antineoplastic activity. Upon administration, ketotrexate competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis. (NCI04)

**Synonyms:** - 5-Methyltetrahydrohomofolate Disodium - Emofolin Sodium - KETOTREXATE DISODIUM - MeTHHF Disodium - Methyltetrahydrohomofolate