Michellamine B

**Semantic type:** Pharmacologic Substance

**Definition:** A natural plant alkyloid with activity against human immunodeficiency viruses (HIV) 1 and 2. Michellamine B inhibits HIV reverse transcriptase (RT) activity and HIV-induced cellular fusion and syncytium formation, thereby inhibiting viral propagation. Michellamine B also inhibits human DNA polymerases alpha and beta.

**Synonyms:** - 6,8-Isoquinolinediol, 5,5'-(1,1'-dihydroxy-8,8'-dimethoxy-6,6'-dimethyl(2,2'-binaphthalene)-4,4'-diyl)bis(1,2,3,4-tetrahydro-1,3-dimethyl)-, (1R,1'R,3R,3'R,5R,5'S)-