Non-nucleoside Reverse Transcriptase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** A substance structurally unlike a nucleoside molecule that is capable of inhibiting the function of a reverse transcriptase. These compounds do not bind to the active site of the polymerase but in a less conserved pocket near the active site, causing a distortion in the shape of the active site and resulting in inhibition of enzymatic function, chain termination, and inhibition of viral replication.

**Synonyms:** - NNRTI