Micellar Paclitaxel

**Semantic type:** Pharmacologic Substance

**Definition:** A systemic administered polymeric micelle containing paclitaxel that may be used for chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis. Paclitaxel, a toxoid, binds to and stabilizes tubulin and inhibits the disassembly of microtubules, thereby inhibiting cell division. Paclitaxel also inhibits metalloproteinase, thereby blocking the activities of matrix metalloproteinases (MMPs) and preventing collagen degradation in cartilage and bone.

**Synonyms:** - Paxceed