DNA Minor Groove Binding Agent SJG-136

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic activity. Following intravenous administration, DNA minor groove binding agent SJG-136 preferentially and covalently binds to purine-GATC-pyrimidine sequences, with the imine/carbinolamine moieties of SJG-136 binding to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links and inhibits both DNA replication and gene transcription, which lead to the inhibition of cell growth. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be susceptible to p53-mediated DNA excision repair.

**Synonyms:** - (11aS,11a'S)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one) - BN2629 - DNA Minor Groove Binding Agent SG2000 - NSC 694501 - Pyrrolobenzodiazepine Dimer - SG2000 - SJG-136 - SJG-136 - SJG136