TP53 Gene Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in the TP53 gene that either inhibits the expression of or results in the translation of an inactive cellular tumor antigen p53 protein.

**Synonyms:** - Inactivating TP53 Gene Mutation - Inactivation of p53 Tumor-Suppressor Gene - LFS1 Gene Inactivation - Li-Fraumeni Syndrome Gene Inactivation - P53 Gene Inactivation - P53 Loss of Function Gene Mutation - P53 Tumor-Suppressor Gene Inactivation - TP53 Loss of Function Gene Mutation - TP53 Tumor-Suppressor Gene Inactivation - TRP53 Gene Inactivation - Tumor Protein p53 Gene Inactivation