Clonal Immunoglobulin Gene Rearrangement

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A DNA sequence rearrangement that results in the creation of a novel immunoglobulin. This process occurs during the differentiation of B-lymphocytes, such that individual B-cell progenitors, and their descendents, express an identical antibody molecule.

**Synonyms:** - Monoclonal Immunoglobulin Gene Rearrangement