PTEN Gene Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A molecular genetic abnormality indicating the presence of an inactivating mutation in the PTEN gene on chromosome 10q23.

**Synonyms:** - Inactivating MMAC1 Gene Mutation - Inactivating Mutated in Multiple Advanced Cancers 1 Gene Mutation - Inactivating PTEN Gene Mutation - Inactivating PTEN Mutation - Inactivating PTEN1 Gene Mutation - Inactivating Phosphatase and Tensin Homolog Gene Mutation - Inactivating TEP1 Gene Mutation - Loss of Function PTEN Gene Mutation - Loss of Function PTEN Mutation - PTEN Loss of Function Gene Mutation - PTEN Loss of Function Mutation - PTEN Tumor-Suppressor Gene Inactivation