SMAD4 Gene Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in the SMAD4 gene that either inhibits the expression of or results in the translation of an inactive mothers against decapentaplegic homolog 4 protein.

**Synonyms:** - DPC4 Tumor-Suppressor Gene Inactivation - Inactivating SMAD4 Gene Mutation - Inactivating SMAD4 Mutation - Loss of Function SMAD4 Mutation - MADH4 Gene Inactivation - MADH4 Tumor-Suppressor Gene Inactivation - SMAD4 Inactivating Gene Mutation - SMAD4 Inactivating Mutation - SMAD4 Inactivation - SMAD4 Loss of Function Gene Mutation - SMAD4 Loss of Function Mutation - SMAD4/DPC4 Gene Inactivation