Anaplastic Large Cell Lymphoma, ALK-Positive

**Semantic type:** Neoplastic Process

**Definition:** A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm. It is characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement.

**Synonyms:** - ALCL, ALK+ - ALK-Positive Anaplastic Large Cell Lymphoma - ALKoma - Anaplastic large cell lymphoma, ALK positive - Anaplastic large cell lymphoma, ALK-positive, unspecified site